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10,11 This body of work has been instrumental in defining how individual cells cross the ferroptotic threshold, although it is increasingly evident that this threshold varies widely across cell types, metabolic states, and tissue contexts

In neurodegenerative contexts, the notable metabolic differences between immature and mature neurons indicate that the lactate-ferroptosis axis during neurogenesis is largely unexplored, with potential implications for neurodevelopmental disorders (199-201)