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Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications
It exhibits antioxidant and otoprotective activity in the cochlea by up-regulating the Nrf-2/HO-1 pathway, while down-regulating p53 phosphorylation.Notably, this action of FA exhibits a biphasic response: it is pro-oxidant at lower concentrations and antioxidant at higher concentrations (Paciello et al., 2020)
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