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69 Conversely, the extracellular release of decorin (DCN, an extracellular matrix-derived damage-associated signaling proteoglycan), 70 high mobility group box 1 (HMGB1, an architectural DNA-binding factor in the cell nucleus), 71 and nuclear receptor coactivator 4 (NCOA4, a mediator of ferritinophagy) 72,73 may function as damage-associated alarm signals that promote inflammatory responses in the local microenvironment
MiR-24-3p was reported to achieve this by blocking the expression of annexin A6 ( ANXA6 ) [82], and miR-128-3p was shown to inhibit their differentiation by downregulating farnesyl diphosphate synthase ( FDPS ) expression, although the specific target genes that promote proliferation remain unidentified [83]
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