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Plateau: Identifying the Cause of Diminished Results Reduced therapeutic effectiveness may indicate degraded medication, though this is difficult to assess without laboratory testing

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The trial showed that tirzepatide achieved roughly 20% weight loss (about 50 pounds) versus 14% weight loss (33 pounds) with semaglutide. This significant difference prompted analysts to declare tirzepatide the winner. As a result, clinicians are updating treatment algorithms and patients on semaglutide are asking about switching