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The key marker is loss of subjective medication effects, not just loss of weight loss
Trace Minerals Selenium Selenium is a cofactor of enzymes that release active thyroid hormone in cells and therefore low levels can cause similar signs and symptoms as iodine deficiency
As expected from previous studies (25), leptin administration significantly reduced food intake and body weight in fasted WT controls (Figure 4, C and E)
PubMed Drge W, Breitkreutz R
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