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Tirzepatide the FDA label directs initiation at 2.5 mg once weekly, with escalation in 2.5 mg steps at intervals of at least four weeks to a maximum of 15 mg weekly

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However, under a chronic glucolipotoxic environment, persistent hyperglycemia disrupts mitochondrial and endoplasmic reticulum homeostasis to trigger extensive oxidative stress and advanced glycation end-product accumulation, which directly activates various intracellular signaling cascades to initiate RCD pathways (14) ( Table 1 )

DOI: 10.3109/09637486.2011.560565, P, H