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Moreover, estrogen was reported to regulate proteolysis through the induction of protease inhibitors, preventing excessive degradation of extracellular matrix components that are essential for tissue repair (Horng et al., 2017)

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Cagrilintide was initiated at 0.3 mg for the 0.3 mg group, or 0.6 mg for all higher-dose groups and escalated every two weeks until reaching the final dose

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