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Tumor progression and metastatic potential IGF-1 LR3 can promote tumor cell invasion and metastasis by upregulating the expression of matrix metalloproteinases (MMP-2/9)
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The structural modifications extend plasma half-life from approximately 1020 minutes for native IGF-1 to approximately 2030 hours for IGF-1 LR3, producing a substantially different pharmacokinetic profile than the native molecule despite identical receptor pharmacology [1]
Sanaka M, Kuyama Y, Yamanaka M
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