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Common Adverse Effects: Nausea Vomiting Constipation Headache These are generally: Dose-dependent Transient Manageable with titration Important Warnings: Potential risk of thyroid C-cell tumors (observed in rodent studies) Not recommended in individuals with a personal or family history of medullary thyroid carcinoma Clinical note: Long-term cardiovascular outcomes data are still emerging, though the class effect suggests likely benefit (Marso et al., NEJM , 2016

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