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Mechanistically, T3 suppresses Cyp8b1 expression, resulting in increased the levels of Farnesoid X receptor (FXR)-antagonistic bile acids, thereby potentiating GLP-1 production and insulin secretion by repressing intestinal FXR signalling
ii) Cardiovascular death: Excluding the SOUL trial strengthened the effect (shifting from non-significant to significant), suggesting sensitivity to SOUL but moderate robustness due to consistent overall effect direction and magnitude
doi: 10.1111/dom.14232 26 ArodaVRBainSCCariouBPiletiMRoseLAxelsenMet al
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