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Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice
What the Research Shows on Weight Loss Clinical trials of bupropion-naltrexone (Contrave) have shown average weight loss of around 5 percent of body weight over one year in patients who also follow a reduced-calorie diet and exercise program
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