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Some users employ a combination approach
0.1% (placebo) Steady State: Achieved after 4-5 weeks of weekly dosing Safety: Nausea (68% at 4.5 mg), vomiting (32%), generally mild-moderate and transient Discontinuation: 14% discontinued due to GI adverse events Appetite Effects: Significant reductions in Visual Analogue Scale (VAS) hunger scores Publication: Lau DCW, et al
However, similar to NOX1 and NOX2, NOX4 can also be regulated by Rac1 and Akt, and protein kinase B signaling pathways (Gorin et al., 2003)
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