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PHQ-9 was already climbing before the escalation finished (12 at week 21), and by week 24, it had reached 17 with HDRS-17 back at 20

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Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1 trial): This study showed that tirzepatide can lead to significant weight loss during active treatment compared with placebo

8 Mayo Clinic recommends choosing a weight or resistance level heavy enough to tire your muscles after about 12 to 15 repetitions. Research cited by Mayo Clinic shows that a single set of 1215 repetitions taken to muscle fatigue can build muscle efficiently in most people. When that becomes easy, gradually increase the weight or resistance. To summarize, a strong starting point is: 23 strength training sessions per week Exercises that target all major muscle groups 2 1 set of each exercise, using a resistance level that leads to muscle fatigue after about 12-15 controlled repetitions