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297 However, overexpression of PINK1 inhibit the mtDNA-cGAS-STING pathway, so impaired mitophagy boosts inflammatory responses by promoting mtDNA DAMPs in aging
The 12mg-cohort escalation consumes 2 + 2 + 2 + 2 + 4 + 4 + 4 + 4 + 8 + 8 + 8 + 8 + 10 + 10 + 10 + 10 = 96 mg over 16 weeks before reaching peak maintenance dose, meaning two 30mg vials cover the full escalation period, and subsequent maintenance can be planned around a 30mg-vial cadence (2.5 weeks of supply per vial at 12mg/week)
By offering an alternative to injections, these capsules eliminate the potential discomfort associated with administering the peptide
It calls the combined result a systemic metabolic recalibration that depends on consistent dosing over weeks
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