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Storage after reconstitution: All three are stable in the refrigerator at 28 C for approximately 28 days after reconstitution

3 Department of Pharmacodynamics, College of Pharmacy, University of Florida, USA

of beef bones (preferably marrow bones, knuckles, and joints) 1 onion, roughly chopped 2 carrots, roughly chopped 2 celery stalks, roughly chopped 4 cloves of garlic, smashed 2 tablespoons of apple cider vinegar (extracts minerals from the bones) 1-2 bay leaves 1 teaspoon of peppercorns Fresh herbs (like parsley, thyme, or rosemary) Sea salt to taste Water Instructions: Prepare the Bones: Optional: For a more robust flavor, preheat your oven to 400F (200C)

Dose-Dependent Adverse Event Patterns One of the clearest findings from published retatrutide data is the dose-dependent relationship with adverse events: Lower doses (1 mg): GI event rates only modestly above placebo Mid-range doses (4-8 mg): GI event rates of 57-64%, with dose escalation reducing peak incidence Highest dose (12 mg): GI event rates of ~67%, though most events were mild-to-moderate and transient The Phase 2 trial included both "single-dose" and "escalated-dose" cohorts for the 4 mg and 8 mg groups