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102 Taken SG3299 as an example, formed by conjugated the DNA-binding pyrrolobenzodiazepine (PBD) payload SG3249 (tesirine) was to an v 6 -specific 20mer peptide from foot-and-mouth disease virus (FMDV) VP1 capsid protein, this v 6 -targeted PDC SG3299 demonstrated significantly greater toxicity (up to 78-fold) against v 6 -expressing cells compared to the non-targeted PDC SG3511 at equimolar doses

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Glutathione is the major free radical scavenger in the brain, lower levels of this antioxidant elevate cellular vulnerability to oxidative stress