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Key Takeaways Retatrutide activates GLP-1R, GIPR, and GCGR simultaneously, making it structurally distinct from both semaglutide (GLP-1 only) and tirzepatide (GLP-1 and GIP only)
Common sites include the stomach, thigh, and upper arm
With 2,339 participants across 80104 weeks, results showed: 28.3% average weight loss at 80 weeks 30.3% at 104 weeks at the 12mg dose That last number is the one making headlines
Each medication may also have contraindications with underlying health conditions you may have or other medications you may be taking, Dr
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