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Kuria A, Tian H, Li M, Wang Y, Aaseth JO, Zang J, et al

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The anti-inflammatory actions of GCs are mediated through transrepression , a process in which the ligand-activated GR, often as a monomer, interacts with and inhibits the activity of pro-inflammatory transcription factors, such as nuclear factor-kappa B (NF-B) and activator protein-1 [23]

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Therefore, a good living environment and a healthy lifestyle are beneficial factors in delaying valvular heart disease and maintaining cardiovascular health

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