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Several reasons mediate the therapeutic potential of temozolomide, including glioma stem cells, O-6-methylguanine-DNA methyltransferase (MGMT) mutations, DNA repair mechanisms, protein kinase B (Akt) pathway, Wnt/-Catenin pathway, Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, autophagy, epigenetic modifications etc., as discussed elsewhere [206]
"Not FDA-approved" just means the FDA hasn't reviewed or signed off on its safety, efficacy, dosing, or manufacturing for people
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