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JCI Insight 2018;3(12):e98333

Furthermore, the included studies were heterogeneous concerning the characteristics of patients and study design (2 of studies on L-carnitine supplementation have been performed in the setting of hemodialysis when carnitine metabolism is altered in uremia and the depletion of carnitine is expected 62 , 4 in diabetic/metabolic syndrome patients with dyslipidemia and 1 in hyperlipidemic patients)

Its monthly dosing, coupled with up to 20% average weight loss at 52 weeks, positions it as one of the first contenders to rival bariatric surgery outcomes