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Allergy to Cobalt or any other ingredient in the supplement - These people should not take B complex vitamins
Published mouse-to-human dose conversion factors typically apply factors of 12-15x reduction per kg
Okada K, Tanaka H, Temporin Ko, Okamoto M, Kuroda Y, Moritomo H, Murase T, Yoshikawa H (2010) Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model
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