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In addition, labelled semaglutide can also cross the blood brain barrier to the caudal lateral septal nucleus (LSc), septofimbrial nucleus (SF), arcuate nucleus (ARC), median preoptic nucleus (MnPO), dorsal vagal complex (DVC)
Notably, some of the treatments that were the most effective have not yet been approved by the FDA for obesity, while the data underscores their potential role in addressing obesity as a chronic disease, the researchers wrote
(Source: PMC / JAMA Surgery, 2025) Bariatric Surgery Volumes Are Actually Declining Despite the outcome data above, the number of bariatric procedures performed nationally has been falling a trend directly tied to GLP-1 adoption
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