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Modern conformal techniques like IMRT (intensity-modulated radiotherapy) help limit radiation to surrounding normal tissues
However, pharmacokinetic studies suggest that these comorbidities do not affect the pharmacokinetics of oral semaglutide, and based on the observed safety profiles, no dose adjustments are recommended [68, 69]
Although case reports have described levothyroxine over-replacement and subsequent AF/Aflutter following GLP-1RA initiation [37], no largescale study has evaluated the real-world effect of GLP-1RA initiation on cardiovascular outcomes
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