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The primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which means insulin is released only when blood glucose levels are elevated Suppressing glucagon release from pancreatic alpha cells, thereby reducing hepatic glucose production Slowing gastric emptying , which delays the rate at which food leaves the stomach and enters the small intestine Reducing appetite through central nervous system effects, promoting satiety and decreasing food intake The slowing of gastric emptying is particularly relevant when considering gastrointestinal side effects
Discontinue use 2 weeks prior to surgery
About 40% of weight reduction comes from lean body mass
Joo 2013
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