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Nonetheless, to date the only FDA- and EMA-approved NRF2 activator for the treatment of relapsing-remitting MS and psoriasis is DMF, and its therapeutic potential in ALS patients in terms of efficacy, safety and tolerability, is now being evaluated in a phase-II clinical trial [313]

In addition to a role in regulating the balance between quiescence maintenance and early activation of MuSCs, we found that Keap1 also has a role in myoblast differentiation as either siRNA-mediated knockdown or genetic knockout of Keap1 delayed myogenic differentiation (Supplementary Fig

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