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On the therapeutic side, the palmitoylation inhibitor 2-bromopalmitate (2-BP) was shown to improve MASH symptoms, which provides an experimental rationale for the development of therapeutic strategies targeting palmitoylation modifications (158)

Specifically, if administered by injection, redness and swelling may occur at the injection site

In this manuscript, the term chronobiotic is used primarily in a functional sense, referring to agents capable of modulating circadian physiology, while acknowledging that only a subset (such as melatonin) fulfills the strict definition of circadian entrainment or phase-shifting agents

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