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Wasting syndromes, elderly mobility studies, and situations where the goal is raw anabolism regardless of side effects

Plant-derived bioactive substances, including polyphenols (flavonoids, phenolic acids, anthocyanins), polysaccharides (inulin, fructooligosaccharides, plant polysaccharides), saponins (ginsenosides, astragaloside IV), and alkaloids (berberine), have been shown to possess multiple biological activities such as gut microbiota modulation, intestinal barrier improvement, reduction of inflammatory factor release, and antioxidant effects (21)

Melanin is what makes the skin colour, and in case of excess production or unevenness, dark spots and pigmentation would be observed

Reczek CR, Chandel NS (2017) The two faces of reactive oxygen species in cancer