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doi: 10.3389/fendo.2026.1822475 Received 03 March 2026 Revised 05 May 2026 Accepted 02 June 2026 Published 18 June 2026 Volume 17 - 2026 Edited by Carmine Bruno, Link Campus University, Italy Reviewed by Matej Rakusa, University Medical Centre Ljubljana, Slovenia Fredrik Tiberg, Camurus AB, Sweden Updates Copyright 2026 Dominikowski, Rko, Olejarz, Szczepanek-Parulska, Domin and Ruchaa

Compounded semaglutide is manufactured by licensed 503A pharmacies under the same FDA quality standards as brand medications, though compounded formulations are not FDA-approved as distinct products

L-carnitine supports fatty acid transport and energy production throughout the body, while acetyl-L-carnitine crosses into the mitochondrial membrane and provides targeted brain health support