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The strongest support comes from clinical evidence focused on treating vitamin B12 deficiency, not from general wellness claims What science supports The NIH Fact Sheet for Health Professionals shows that intramuscular B12 injections are effective at raising blood B12 levels and correcting deficiency

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Reddit users following optimized protocols (fasted injections, caloric deficit, consistent timing) report noticing initial changes in body composition measurements within 2-3 weeks, with visible fat loss becoming apparent at 4-6 weeks