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Emerging research suggests GLP-1s may directly affect the skin by reducing collagen production, accelerating glycation (which stiffens and weakens collagen fibers), and diminishing hydration levels

The STEP 1 trial, published in the New England Journal of Medicine in 2021, showed that participants taking semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group

What happens if you do not rotate retatrutide injection sites

If you experience bothersome side effects, your provider may modify your dose increase or adjust your overall treatment approach