is semaglutide off patent Ozempic's problem: how Novo Nordisk lost control of a blockbuster drug. 💉 Demand for GLP-1 weight-loss drugs has exploded, turning Ozempic into a $40bn+ revenue engine for Novo Nordisk. But, despite A Snapshot of the Semaglutide

Neuroprotective effects of GLP-1R agonists GLP-1 and its mimetics can cross the BBB, therefore, are able to affect the CNS function such as cognition and neuroprotection (138)

Elokda AS, Shields RK, Nielsen DH

Protein digestion Protein concentration was estimated by BCA assay (Pierce) and the lysates were digested with Lys-C (Wako) in an enzyme/protein ratio of 1:100 (w/w) for 1 h followed by a threefold dilution with 25 mM Tris, pH 8.5 to 2 M GdmCl and further digested overnight with trypsin (Sigma-Aldrich) 1:100 (w:w)

These findings suggest that the cardiovascular benefits observed in the study were more closely associated with attained semaglutide dose than with weight loss alone