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189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level
Peer review Peer review information Nature Communications thanks Mitsuyasu Hasebe, Hiroaki Mano, Andrej Pavlovic and Michael Wudick for their contribution to the peer review of this work
Finally, the DPP-4, responsible for degrading biologically active peptides like opioids and GLP-1, has emerged as a target for enhancing GLP-1 levels [7, 34, 35]
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