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Lead (Pb)-induced oxidative stress and toxicity reduced the expression of selenoprotein mRNAs, and the effect was mitigated by selenium supplementation 129
Unlike traditional insulin secretagogues, Prusogliptin does not directly stimulate insulin release but rather enhances endogenous GLP-1 activity, resulting in a lower risk of hypoglycemia and less likelihood of weight gain
The Health Concerns By 2023, patients and doctors began reporting: Gastroparesis (stomach paralysis) Gallbladder disease (sometimes requiring surgery) Severe nausea, vomiting, and diarrhea Intestinal blockages A rare eye condition: NAION (a type of optic nerve damage) In response, the FDA updated the drugs warning labels to list risks like gallbladder disease, abdominal pain, constipation, diarrhea, nausea, and vomiting
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