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doi: 10.2337/dc16-0690 28 MathieuCZinmanBHemmingssonJUWooVColmanPChristiansenEet al
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Oxidative stress is a critical factor contributing to the age-associated decline in oocyte quality ( 2.2 Oxidative stress results in a reduction in chromosomal cohesion Chromosomal cohesion is facilitated by adherin proteins, which are established during the early stages of embryonic development ( 2.3 Oxidative stress results in aberrant spindle assembly The spindle assembly in human oocytes exhibits instability
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