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IL-13 exerts its anti-angiogenic function via activation of protein kinase C (PKC) / II and ERK-1/2, with concomitant down-regulation of the NF-B/p65 pathway (90), and it also can reduce the death of chondrocytes to protect the cartilage from destruction probably because of the reduction of Fc gamma receptor I (FcRI) (91)
9 In a 2022 study on Mounjaro found that 85% of participants had a weight reduction of 5% or more over 72 weeks of use and those on the highest dose (15 mg) achieved the biggest lose: -23.6kg, versus -2.4kg with the placebo
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doi:10.1016/j.jogoh.2020.101698
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