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Fillenbaum GG, van Belle G, Morris JC, Mohs RC, Mirra SS, Davis PC, et al

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Upon activation, phosphorylated MLKL (p-MLKL) oligomerizes and translocates to the cell membrane, forming pores that disrupt electrochemical gradients, resulting in lytic cell rupture and the release of damage-associated molecular patterns (DAMPs), inflammatory cytokines and chemokines

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