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Quick Answer: In clinical trials, tirzepatide has generally shown a higher percentage of total body weight loss compared to semaglutide

Small-molecule degradation typically just produces less active compound

What makes AOD-9604 unique is its selective action on fat metabolism without producing the other effects associated with full-length human growth hormone, such as increased blood glucose levels, insulin resistance, or excessive IGF-1 production

I think that is really what grabbed people and got them excited about it. Furthermore, similar to how semaglutide has been found to offer additional health benefits beyond weight loss, such as lowering heart attack risk, and tirzepatide was approved by the FDA for the treatment of sleep apnea, retatrutide is being studied as a potential treatment for other health concerns