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Folate dependency most likely is the reason for the impaired nucleotide synthesis in the Arabidopsis folate biosynthesis dfb mutant, which is defective in the plastidial isoform of the folate biosynthetic gene folylpolyglutamate synthase (FPGS1, designated as AtDFB
& Oh, M
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EX-4 affects the microglia (immune cells in the brain) through an autocrine mechanism, in which interleukin-10 (IL-10) mediates -endorphin expression
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