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Among them, GPX4 is a membrane-associated phospholipid hydroperoxidase, and it is also the only enzyme in the GPX family that directly reduces and destroys lipid hydroperoxides, which can reduce complex lipid compounds in addition to reducing H 2 O 2 and small molecule hydroperoxides
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Particularly during the luteal phase or under the influence of exogenous progestogens, it promotes mitotic effects and strongly stimulates the proliferation of fibroid cells [Citation36]
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