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However, additional concerns have been noted, including modest increases in heart rate observed in clinical trials and reports of dysesthesia, where normal sensations are perceived as painful, in some users
Combination approaches integrating metabolic inhibitors with chemotherapy, radiotherapy, or immunotherapy are emerging as promising strategies to overcome resistance and improve clinical outcomes
The most common adverse effects are gastrointestinal, including nausea, vomiting, and diarrhea
The liver and small intestines were taken from the rats
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