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In the comparison of oral semaglutide with dulaglutide, the largest increase in the ICER was observed when applying only differences in treatment effects that were statistically significant in the NMA, where the only difference between the treatment arms was the change in BMI

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Research in animal models has clarified the dual pathway mechanism

For example, Medicare Part D plans still require beneficiaries to pay premiums and cost-sharing, and those without supplemental coverage or who do not qualify for the Low-Income Subsidy face higher financial barriers