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Finally, the C-terminal Neh3 domain is another transactivation domain that recruits chromo-ATPase/helicase DNA-binding protein 6 (CHD6), functioning as an NRF2 transcriptional coactivator [153] (Fig
We have previously demonstrated that these fluxes of cytosolic glutamate can occur without detectable increases in oxidative stress or altered cell viability (16)
Succinate is also proinflammatory and induces mtROS production and IL-1 expression (Banoth and Cassel, 2018)
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