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Michael Weintraub, an endocrinologist at NYU Langone Health
At the metabolic level, dysbiosis can disrupt bile acid metabolism by increasing hydrophobic toxic bile acids while suppressing intestinal FXR signaling and fibroblast growth factor 19 (FGF19) expression, thereby relieving the negative feedback inhibition of hepatic cholesterol 7-hydroxylase (CYP7A1) and promoting bile acid pool expansion and hepatocellular lipotoxicity [285, 286]
doi:10.1177/1933719119828099
Insulin injection and dosing errors in diabetes: a systematic review
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