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The mechanisms and regulation of autophagy and mitophagy have attracted considerable attention due to their impact in health and disease and have been recently reviewed (Saberi et al., 2014), thus complementing the JNK-dependent contribution of PKC in APAP hepatotoxicity described above

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MiRNAs are hypothesized to target at least 60% of genes in humans and because they are evolutionarily conserved, they are assumed to be important for biological functioning [15]

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