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Central GLP-1R activation in hypothalamic and mesolimbic pathways may lead to fatigue, lethargy, or brain fog 63 , though such effects might be often transient and dose-dependent
Metformin is a commonly used biguanide that can be used as an alternative to Tirzepatide
Clinical trials focusing on this combined approach could provide valuable insights into optimizing treatment for men with obesity or type 2 diabetes and low testosterone levels
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