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10.1074/jbc.M116.748814 23 DohiE.TanakaS.SekiT.MiyagiT.HideI.TakahashiT.et al (2012)
While acetaminophen itself does not produce cravings or compulsive drug-seeking behavior, its presence in opioid formulations contributes to prolonged misuse, increasing the likelihood of opioid addiction
Sauer N, Magorzata Olizo, Brzostek M, Wolska J, Katarzyna Lubaszka, Katarzyna Karowicz-Bodalska
If your side effects are unpredictable, start with evening dosing for the first 4 to 6 weeks as you establish your dose
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