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This creates a feedback loop that preserves neuronal viability in MPTP-induced models

EMBO Rep 7 , 11 (2006)

Animal Model:Neonatal Sprague-Dawley rats (male, 18-22g, postnatal day 7), hypoxic-ischemic brain damage (HIBD) model [2] Dosage:100 mg/kg Administration:Intraperitoneal injection, once daily, for 14 consecutive days starting 24 hours after HIBD induction Result:Brain injury: Reduced infarct volume by 40% compared to the HIBD control group as measured by triphenyltetrazolium chloride (TTC) staining

In the same study, patients were followed for an additional 12 weeks after the last dose of bimagrumab and experienced no weight regain