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TAZ inhibition in hepatocytes also reduces the activation of HSCs by decreasing Indian hedgehog (IHH) signaling ( 4 -induced liver fibrosis models suggests that neutrophils may also participate in fibrosis resolution by secreting MMP8 and MMP9 ( Figure 4E )

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N Engl J Med 376(24):23492357 Cherney DZI, Perkins BA, Soleymanlou N, Maione M, Lai V, Lee A et al (2014) Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus

The expression level of the voltage-dependent anion channel controls life and death of the cell