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Additionally, metformin inhibits mitochondrial respiratory chain complex I, which lowers proton leak and ROS generation in hepatocyte mitochondria, thereby reducing hepatocyte apoptosis to treat DILI (99)
Qualitative assessment of nitric oxide production by fluorescent dye 3-Amino-4-aminomethyl-2,7-difluorescein, diacetate (DAF-FM DA, Sigma) HUVECs grown in M199 based culture medium was stimulated with 1.0 g/ml BPC 157 for 30 min to induce the nitric oxide generation
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