semaglutide off the market Off-patent in 2026: next revolution in anti-obesity medications Cheaper semaglutide alternatives to Wegovy

When to contact your GP: Persistent or severe nausea/vomiting preventing adequate fluid intake Severe, persistent abdominal pain which could indicate pancreatitis New or worsening depression, anxiety, or suicidal thoughts Severe headaches or visual disturbances Unexplained cognitive changes or confusion Signs of hypoglycaemia (if taking alongside insulin or sulfonylureas) NICE guidance recommends regular monitoring during GLP-1 receptor agonist therapy

Oral tirzepatide formulations are in development

When we talk about "reduced forms," we're referring to molecules that have undergone a chemical change by gaining electrons

The clinical importance is clear: this is the first GLP-1 generic approved specifically for weight loss, not just for diabetes